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Wham is made for paired-close Illumina libraries with standard insert dimensions (~300bp-500bp). Wham integrates mate-pair mapping, split go through mapping, smooth-clipping, different alignment and consensus sequence dependent proof to forecast SV breakpoints with one-nucleotide accuracy. Wham generates a mixed pileup (catalog of reads covering a
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The delicate-clipped sequences that overhang the breakpoint are collapsed right into a consensus sequence utilizing a numerous sequence alignment (MSA) presented inside the seqAn library [27]. Wham applies 3 filters for the consensus sequences. Breakpoints usually are not claimed in cases in which consensus sequences are shorter than 10 bp or have